Journal of Fertility and Reproductive Health

ABSTRACT

Reproductive tissue damage caused by congenital disorders, aging, disease, or medical treatments poses significant challenges to fertility and reproductive health. Recent advancements in regenerative medicine, particularly the integration of stem cell biology and tissue engineering, offer new therapeutic possibilities for restoring reproductive function. This review highlights current developments in the application of stem cells, such as embryonic stem cells, mesenchymal stem cells, induced pluripotent stem cells, and germline stem cells, in reproductive tissue engineering. These cells, in combination with biocompatible and biodegradable scaffolds, have been explored for regenerating ovarian, uterine, testicular, and endometrial tissues. The design of biomaterial scaffolds that support stem cell differentiation, vascularization, and host integration is a critical focus. Additionally, the emergence of 3D bioprinting, organoid culture, and gene editing technologies has expanded the potential for creating functional reproductive tissues. While early-stage research and preclinical models show promise, clinical translation remains limited due to concerns about immune rejection, tumorigenicity, and long-term efficacy. Ongoing research aimed at overcoming these barriers may soon enable the development of personalized, stem cell-based therapies for treating reproductive disorders and infertility.

Article History

Received 07 February 2025;Revised 28 February 2025;Accepted 07 March 2025

KEYWORDS

1. Tissue engineering
2. Regenerative medicine
3. Biocompatible materials
4. Bioprinting
5. Gene editing